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despite the project s successful management to date, uncertainty raises important concerns that need to be addressed to the satisfaction of those granting sanction; 3 there is suf cient time to undertake a comprehensive RMP If these three characteristics apply, rst-time formal risk management toward the end of the plan stage of a project can be comparatively rewarding and troublefree The essence of the argument is learn to walk in well-charted terrain before you try to run on dif cult, more uncertain terrain , and learn about the terrain as a whole before you attempt short cuts under pressure This point is discussed in more detail in 15 We hope the reader interested in direct application of the ideas developed in this book will be able to try them out for the rst time in the plan stage of a carefully selected project.

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Even if the technology were more mature and privacy protections were stronger, however, the promise of individualized treatment may never be fully realized by pharmacogenomics for the very practical reason that it is more cost-effective to research and develop therapies that will be used (and paid for) by the largest groups of people possible (Rothstein and Epps, 2001b) At the same time, critiques of the use (and misuse) of race and ethnicity as diagnostic and therapeutic proxies have become increasingly prominent in biomedicine (Oppenheimer, 2001; Schwartz, 2001) Critiques also have been made of their use in genetics research and genetic medicine (Foster et al, 2001; Graves, 2001) In many ways, dividing study participants and patients by race and ethnicity is akin to using a meat cleaver to prepare a slide for an electron microscope.

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If an RMP is applied for the rst time on a non-voluntary basis, the plan stage of a project is the most likely point at which it will be required The requirements of banks and boards motivate many rst-time users to employ an RMP, and the plan stage is usually when this requirement can no longer be avoided Moreover, prudent boards and banks will insist on a comprehensive RMP if rst-time users of RMPs are involved..

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The resulting extended categories are overly inclusive and do not re ect biological de nitions of population, while they exclude some individuals who may share the genetic feature(s) in question Although race and ethnicity may, one day, no longer be used as medical proxies, social constructions of identity nonetheless will continue to affect the ways in which we conceptualize pharmacogenomic ndings and applications Thus it is a useful exercise to ask how new groups formed by the alternative process of narrowing may affect pharmacogenomics The genomic technologies that we already or soon will have can make a number of.

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By conversing with your customers online, you can tap into all of this and give them another reason to stay in the relationship: You care enough about what they think to make it easy for them to talk to you. Indeed, they are likely to refer their friends. Any organization whose stakeholders establish lasting, mutually beneficial relationships with it has gained a powerful asset.

The Parlay API offers a secure, controlled, and accountable common interface across networks, allowing applications to be created that are both network transparent and implementation transparent It is envisioned that the introduction of the Parlay API into the monolithic telecommunication networks will greatly stimulate third-party service providers to create a wide range of innovative value-added services rapidly and inexpensively Further down the road, the next step of the integration of telecom networks and IT applications is to provide access to these direct programmatic interfaces using web services, which will bring in a much wider application developers base and additional business potential It has been claimed that the integration of Parlay API and web services is both commercially pro table and technically feasible (Parlay 2002a,b,c) We discuss this brie y here.

However, it is possible to de ne a simple algorithm that systematically computes a generative family of ows [COU 90] by adding a new rule to the two previous ones. This new rule is based on the use of the generalized inverse or pseudoinverse of a matrix [NAS 76]. DEFINITION 8.11 (Pseudoinverse [NAS 76]). Let f be a linear mapping from BagQ (C1 ) to BagQ (C2 ). A non-unique mapping h from BagQ (C2 ) to BagQ (C1 ) exists such that f h f = f . Such a mapping is called a pseudoinverse or a generalized inverse of f . Furthermore, (Id f h) is a generative solution of the equation X f = 0.

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